yes you can
just empty the table.
You will loose all your stats though...
but nothing else then that

I empty evo_sessions and evo_hitlog before I backup.

You can also empty the antispam table, as that is easily repopulated once your new installation is running.

Also, a good way to reduce your hitlog size without fiddling with mySQL is to change the pruning setting, which controls how many days of hits you keep. For a busy blog the default can easily create a very big file.

Find the pruning setting on Global Settings/ Features/ Hit & Session logging in 2.x, or App Settings / Features/ Autoprune in 1.x.

To make the hitlog smaller, reduce the number in the box.